ACE2 and obesity due to melanocortin 4 receptor deficiency: Possible reasons for severe COVID-19 disease amongst obesity patients include: (1) Angiotensin-converting enzyme 2 (ACE2) is a binding receptor with high affinity for COVID-19, where higher levels of ACE2 ribonucleic acid (RNA) were found in the heart, kidneys, intestinal tract, gallbladder, adipose tissue, testicles and in lungs, which could explain multi-organ dysfunction in patients with severe COVID-19.3,10 Patients with obesity carrying excess amount of adipose tissue rich in ACE2 receptors would make them more vulnerable to acquire COVID-19 and possible severe disease progression.