OXT and Tako-tsubo cardiomyopathy: This has been found in the association between cumulative stress and disrupted hypothalamic-pituitary-adrenocortical axis functioning,13 lower oxytocin level in pregnant women14 and Takotsubo cardiomyopathy.15 This adds to the known detrimental effect of psychological stress on health (e.g. immunoregulatory balance) and the association with inflammatory disease,16 cardio vascular disease,17 immune system18 and immune inflammatory reactions.19 Psychological stress also takes an economic toll directly and indirectly, and increases the burden on the health system.20