Through gender stratification, our analysis ascertained that females with CYP24A1 polymorphism rs6013905 AX (P = 0.04, OR = 2.59, 95%CI: 1.03–6.49), rs2762939 GX (P = 0.01, OR = 2.35, 95%CI: 1.25–4.42), and rs6068816 GG (P = 0.05, OR = 1.89, 95%CI: 0.99–3.59) carriers were significantly associated with CRC (Fig 2, S3 Table in S1 File). The gene discussed is CYP24A1; the disease is colorectal carcinoma.