Several researches have investigated the association between 18F-FDG PET findings and tumor HPV/p16 status in patients with HNSCC (Joo et al. 2014; Kendi et al. 2015; Chen et al. 2017; Tahari et al. 2014; Surov et al. 2019; Schouten et al. 2016; Huang et al. 2015). Here, CDKN2A is linked to head and neck squamous cell carcinoma.