In the clinical setting, sepsis-induced brain dysfunction as determined by altered neuroinflammatory markers, magnetic resonance imaging (which revealed morphological alterations in approximately 2/3 of the patients), and clinical parameters (such as the Glasgow outcome score extended) has shown enhanced C4d but significantly reduced systemic iC3b and C5a concentrations in patients with cerebral lesions [136]. Here, C5 is linked to Sepsis.