However, in some disease models, inhibition of proximal complement pathways has resulted in remarkable benefits calling for further studies that dissected the role of the many different complement activation products upstream of C5 activation (e.g., C3a, C3b, iC3b, C3dg, C4a, C4b, iC4b) in trauma, burn, and sepsis. The gene discussed is C4A; the disease is Sepsis.