APLN and type 2 diabetes mellitus: In this interaction network, most significant emergent pathways were those of apelin, insulin, FOXO, AMPK, T2DM and glycolysis/gluconeogenesis signaling, and deregulation of any of these pathways might promote irregular skeletal muscle metabolism and growth and this has been reported to be causative to several irregularities associated with the diabetic phenotype [68–70].