Thus, as a Ca2+-dependent non-selective monovalent cation channel (Constantine et al., 2016; Launay et al., 2002; Nilius et al., 2003; Nilius et al., 2005), TRPM4 could contribute to TAC-induced LVH by modulating downstream voltage-gated Ca2+ ion channels or the Na+/Ca2+ exchanger (Figure 6). Here, SLC8A1 is linked to persistent truncus arteriosus.