TRPM4 and persistent truncus arteriosus: To further investigate the role of TRPM4 channels in pressure overload-induced LVH, we performed TAC or sham surgery in mice with cardiomyocyte-specific, conditional deletion of Trpm4 (Trpm4 cKO) using Cre expression driven by the Myl7 promoter (Kecskés et al., 2015).