To date, there are three major transgenic Drosophila AD models: the γ-secretase-based model (Guo et al., 1999; Ye and Fortini, 1999), the Tau-based models (Jackson et al., 2002; Wittmann et al., 2001), and the amyloid precursor protein (APP) or Aβ42-based models (Casas-Tintó et al., 2011; Crowther et al., 2005; Finelli et al., 2004; Jeon et al., 2020). Here, MAPT is linked to Alzheimer disease.