MAPT and Alzheimer disease: The ‘amyloid cascade hypothesis’ is pointed as the leading theory explaining AD pathophysiology, proposing that insoluble Aβ plaques are the major inducers of neuronal apoptosis and neurodegeneration, as well as Tau (also known as MAPT) pathology (Akhter et al., 2014; Hardy, 2002; Oddo et al., 2003).