Distinct interaction patterns between protein aggregates – huntingtin in HD, amyloid-β in AD, α-synuclein (α-syn) in PD – and neurons might explain the differing symptoms and neuronal stages observed in some NDDs (Babcock and Ganetzky, 2015; Roussarie et al., 2020; Sawa et al., 2003; Surmeier et al., 2017). Here, HTT is linked to Parkinson disease.