Irisin is a myokine associated with increased energy expenditure due to its ability to stimulate browning of white adipose tissue, which is secreted after exercise.[39] Irisin levels are reported to be low in obese individuals, patients with T2DM, and coronary artery disease.[40–42] Liu et al[41] showed that irisin levels were lower in long-standing T2DM patients than in non-diabetic controls. This evidence concerns the gene FNDC5 and type 2 diabetes mellitus.