It was observed that the circulating myostatin concentrations correlated with IR, myostatin expression and secretion increased in skeletal muscle and adipose tissue samples obtained from obese and severely obese women.[11] Myostatin levels are increased in T2DM patients.[38] In our study, myostatin levels were similar in patients with and without sarcopenia, which may be due to the low number of cases in our study. This evidence concerns the gene MSTN and type 2 diabetes mellitus.