In programmed cell death protein 1-deficient mice, immunoglobulin G (IgG) was found to be deposited on the surface of cardiomyocytes, suggesting that the autoimmune system is involved in the disease progress of DCM.[7] In DCM patients, removal of antibodies by immunoadsorption (IA) can improve hemodynamic. The gene discussed is PDCD1; the disease is familial dilated cardiomyopathy.