They also produce growth factors related to tissue proliferation and angiogenesis that promote tumor recurrence and metastasis, such as interleukin-10 (IL-10), transforming growth factor -beta, epidermal growth factor, insulin-like growth factor, vascular endothelial growth factor, PLT-derived growth factor and similar.[21] GM-CSF was the determinant of malignant tumor cells-mediated neutrophil production of hepatocyte growth factor. This evidence concerns the gene CSF2 and cancer.