In agreement with our previous work,12 we confirmed in T84 adenocarcinoma model IECs the ability of butyrate to stabilize HIF through the induction of HIF-1α target genes BNIP3, BNIP3L, and GLUT1 (Figure 2a), similar to dimethyloxalylglycine (DMOG), a 2-OG analogue with broad-spectrum inhibition of PHDs, and IOX2, a more PHD2-specific inhibitor.10,12,16 HIF-1α protein levels were also increased with butyrate (Figure 2(b,c)). Here, BNIP3 is linked to adenocarcinoma.