Increased 2-OG from PHD inhibition drives production of kynurenine, which protects against cardiac ischemia.17 Kynurenine, as a tryptophan derivative, promotes intestinal wound healing and alleviates murine colitis,48 but can be a downstream beneficial influence of accumulated 2-OG from butyrate PHD inhibition. Here, PDC is linked to myocardial ischemia.