Other significantly enriched pathways in the penta-cultures containing platelets were immune system (cytokine production, most likely triggered through platelet action), post-translational modifications, hemostasis (indicative of the presence of platelets including platelet degranulation, and response to elevated platelet cytosolic Ca2+), smooth muscle contraction (that is associated with stromal cell activation in response to tumor invasion), and circadian clock (Figure 3A). This evidence concerns the gene CLOCK and neoplasm.