VCAN and cancer: To further explore whether platelets were stimulating the production of a poor prognosis ECM, we assessed two of the ECM molecules identified in our previous study on human HGSOC cancer tissue (Pearce et al., 2018) that associated with poor prognosis, namely versican (VCAN), and fibronectin (FN1), within tetra- and penta-cultures (Figure 4A).