CXCL5 and cancer: Other top differentiated genes that resulted from the presence of platelets included cancer-associated inflammatory cytokines CXCL5 and CCL5 which are associated with invasiveness, metastasis (Romero-Moreno et al., 2019; Singh et al., 2018) and platelet guided formation of a metastatic niche (Labelle et al., 2014).