ALPL and hypophosphatasia: Rauch and colleagues examined a cohort of patients with hypophosphatasemia and rheumatologic symptoms in an adult metabolic bone clinic and performed ALPL sequencing.(18) Heterozygous pathogenic or likely pathogenic ALPL variants were identified in 14 of 24 (58%) patients.(18) The present study adds to the case‐finding strategy by HPP clinical manifestations and low ALP levels.