indicated that m6A-modified circNSun2 in the nucleus could be recognized by YTHDC1 and exported to the cytoplasm, and circNSun2 then stabilizes high mobility group AT-hook 2 (HMGA2) mRNA by forming the circNSun2/insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)/HMGA2 complex; lastly, CRC cell invasion and liver metastasis are caused. This evidence concerns the gene HMGA2 and colorectal carcinoma.