METTL3 and hepatocellular carcinoma: For example, METTL3 promotes tumorigenesis of breast cancer (BC), acute myeloid leukemia (AML), and hepatocellular carcinoma (HCC) by enhancing m6A modification.79, 80, 81 METTL14 inhibits the growth and self-renewal of glioblastoma stem cells (GSCs) by enhancing the m6A modification of ADAM19 and reducing its expression in glioblastoma multiforme (GBM).82