Interestingly, the identification of death receptor signalling mediated via the FADD and TNFRSF10B (TRAIL‐R2) signatures was also implicated as a key mediator of CAR‐T cell cytotoxicity, which further elucidate the RIPK1‐dependent mechanism of SMAC mimetic sensitisation of diffuse large B‐cell lymphoma cells and B‐cell acute lymphoblastic leukaemia to anti‐CD19 CAR T cells.50 Here, TNFRSF10B is linked to precursor B-cell acute lymphoblastic leukemia.