For example, the mechanism of MM cell lines susceptibility to immunomodulatory imide drugs (IMiDs) was explored by loss‐of‐function genome‐wide screening and found that COP9 signalosome complex subunit 9 mediates the regulation of cereblon, which serves as the main factor responsible for sensitivity of MM cells to IMiDs.46 This evidence concerns the gene COPS8 and Miyoshi myopathy.