As a proof of concept, genome‐wide CRISPR screening has been used to identify an uncharacterised protein CKLF‐like MARVEL transmembrane domain‐containing protein 6 (CMTM6), which serves as a critical regulator for the surface expression of PD‐L1 – whose increased expression also correlated with enhanced tumor cell clearance with ICBs.121. This evidence concerns the gene CD274 and neoplasm.