Mima et al. reported that a high prevalence of F. nucleatum was associated with poor differentiation, advanced disease stage, and cancer-specific survival [45], suggesting a specific colorectal carcinogenic effect of F. nucleatum. Ito et al. reported that a high prevalence of F. nucleatum was associated with MLH1 methylation, CpG island methylator phenotype (CIMP), and microsatellite instability-high (MSI-H) in CRC [51], suggesting that F. nucleatum is associated with specific molecular features in CRC. Here, MLH1 is linked to cancer.