A meta-analysis performed on 12 observational prospective cohort studies inadults demonstrated that the development of ADA reduced the anti-TNF responserate (RR) by 68% [RR = 0.32; 95% confidence interval (CI) 0.22, 0.48],85 while in children with JIA, a qualitative analysis found that antibodiesto infliximab and adalimumab were associated with treatment failure.35 Here, TNF is linked to juvenile idiopathic arthritis.