In CRC, only one study more than two decades ago reported that treatment of differentiated Caco2 cells with forskolin could stimulate adenylate cyclase and raise intracellular cyclic AMP levels to raise SLC2A5 expression by cis-acting regulatory sequences.40 However, this study was not widely persuasive due to the limitations of cell line selection. The gene discussed is ADCY1; the disease is colorectal carcinoma.