SHC3 and gastric cancer: Study has reported that the demethylation of the upstream promoter of Shc3 increased the expression of Shc3 to induce EMT and promote HCC cell metastasis.60 Melanoma antigen (MAGE)-encoding genes were expressed in advanced gastric cancer via demethylation of promoter CpG islands.61 There are two main ways of DNA demethylation.