TWIST1 and colorectal carcinoma: It is characterised by the downregulation of genes encoding for epithelial cell junction proteins (E-cadherin, claudins, etc.)and the activation of some genes, among which the protein products (N-cadherin and vimentin, etc.)promote mesenchymal adhesion.41 The transition from epithelial to mesenchymal morphology and the loss of cell adhesion are orchestrated by various transcription factor families (EMT-TFs) such as Snail, Twist and Zeb.42,43 We supposed that EMT might be involved in the process of SLC2A5 regulating the distant metastasis of CRC cells.