It is characterised by the downregulation of genes encoding for epithelial cell junction proteins (E-cadherin, claudins, etc.)and the activation of some genes, among which the protein products (N-cadherin and vimentin, etc.)promote mesenchymal adhesion.41 The transition from epithelial to mesenchymal morphology and the loss of cell adhesion are orchestrated by various transcription factor families (EMT-TFs) such as Snail, Twist and Zeb.42,43 We supposed that EMT might be involved in the process of SLC2A5 regulating the distant metastasis of CRC cells. This evidence concerns the gene ZEB1 and colorectal carcinoma.