Based on our previous study underlying the mechanism of S100P in driving CRC metastasis, we found that S100P was also abundantly expressed in the nucleus.13 In consideration of the potentially transcriptional function of S100P, we performed ChIP-sequencing analysis and found that S100P could interact with multiple genes, in which the promoter of SLC2A5 gene showed the most obvious interaction with S100P. This evidence concerns the gene S100P and colorectal carcinoma.