MTOR and cocaine use disorder: In humans with Cocaine use disorder, the vmPFC exhibits a time-dependent hyperactivity in response to drug-associated stimuli (e.g., [11, 12]), and interrogation of the vmPFC and NAc in rodent models of incubated cocaine-craving highlights anomalies in Group 1 metabotropic (mGlu) and calcium-permeable AMPA-type glutamate receptor expression which may reflect, for instance, deregulated mammalian target of rapamycin (mTOR) function [13, 14], as one driver of this phenomenon.