However, PTX3 immunostaining was seen in the stroma of human PDAC, as well as in the most commonly used transgenic mouse model of PDAC, KrasLSL.G12D/+, p53R172H/+, PdxCretg/+ (KPC) mouse, with no immunoreactivity in most cancer cells except those within peri-neural invasion (Fig. 2A, Supplementary Fig. 2A–B). The gene discussed is PTX3; the disease is cancer.