The facts that (1) 7 patients (6 families with missense mutations, including Patients 6-1 and 6-2 from Family 6) share extremely rare NEUROD2 variants with pathogenic prediction and similar NDD/ASD symptoms, (2) Patients 1 and 5 carry the same mutation (p.Glu130Gln) and show the same symptoms, and that (3) inheritances of His268Gln mutation and NDD symptoms are co-segregated in Family 6, strongly reinforce the notion of a causative link between NEUROD2 mutations and NDD. This evidence concerns the gene NEUROD2 and Neurodevelopmental delay.