HPGDS and osteoarthritis: Few examples include: Diacerein (current usage: osteoarthritis) against tuberculosis (predicted Mtb target: Lanosterol 14-alpha demethylase), Afatinib (anti-cancer agent) against candidiasis (predicted C_alb target: Cyclin-dependent kinase-1), and Tranilast (anti-allergic drug) against malaria (predicted P_fal target: Glutathione S-transferase).