For this reason, a couple of semi- or fully-automatic Hb segmentation approaches have been reported: (1) reproducibility of a myelin content-based Hb segmentation from 3 T magnetic resonance imaging (MRI) using a semi-automatic myelin contrast-based method14, and (2) a machine learning algorithm for fully-automatic Hb segmentation of 1.5 T MRI for Hb volume comparison of patients with bipolar disorder and schizophrenia with healthy controls15. This evidence concerns the gene GSTM1 and bipolar disorder.