In this study, we were able to find that the serum antibody levels against some of the SEREX antigens were elevated in patients compared with healthy donors (HDs) and reported TROP2, SLC2A1, TRIM21, and myomegalin as antibody biomarkers for esophageal squamous cell carcinoma (ESCC)13–16. Here, TRIM21 is linked to esophageal squamous cell carcinoma.