TP53 and neoplasm: While p53−/− versus p53+/+ AOM/DSS mice have accelerated tumor growth (larger tumor numbers and sizes, Supplementary Fig. 2g–j) due to reduced cell cycle inhibitory/pro-apoptotic p53 target gene expression (Supplementary Fig. 2k, l), only some HSF1 target genes increased (Supplementary Fig. 2m).