HSF1 and infectious otitis media: AOM/DSS CRCs require WTp53 activation by Nutlin (mimicking high proliferative stress or chemotherapy) to fully regulate HSF1 (Fig. 2e and Supplementary Fig. 2d, e), patient p53LOH tumors intrinsically exhibit upregulated HSF1 targets compared to WTp53 tumors (Fig. 6).