Thus, we treated tumor-bearing p53Q/+ mice with Nutlin, a highly specific non-genotoxic p53 activator inhibiting its E3 ligase MDM2, to mimic the general activation state of WTp53 in tumors constitutively stressed by aberrant growth, metabolic stress, hypoxia, and genomic instability (Fig. 2a). This evidence concerns the gene TP53 and neoplasm.