ZEB1 and osteosarcoma: 91 In rhabdomyosarcoma and osteosarcoma cells, miR-200 inhibits ZEB1 and thereby induces E-cadherin and co-expression of miR-200 and grainyhead‐like transcription factor 2 (GRHL2) results in a multiplicative increase in E-cadherin and morphological changes consistent with MET.92 More is known about EMT/MET processes in osteosarcoma cells since several factors including TGF-β, microRNAs (miRs), BMP-2 and Interleukin-33 (IL-33) have been identified to regulate these processes.