For example, in osteosarcoma patients, those with VEGF-positive tumors had a significantly higher incidence of pulmonary metastases and worse overall survival compared to those with VEGF-negative tumors.79 Finally, overexpression of VEGF in STS cell lines led to accelerated growth and formation of highly vascular tumors, pulmonary metastases and chemoresistance in experimental models in vivo.80 The gene discussed is VEGFA; the disease is telomere syndrome.