YAP1 and neoplasm: The treatment of ARMS and ERMS with the DNA methyltransferase inhibitor guadecitabine (PubChem CID: 135564655) also reduced cell growth, induced apoptosis and differentiation, and repressed ARMS tumor growth in vivo; this occurred by activating canonical Hippo signaling and downregulating YAP1, a known tumor promoter of RMS.196