For example, miR-143 downregulates MMP-13 to suppress osteosarcoma cell invasion and metastasis, and exosome-mediated delivery of miR-143 to osteosarcoma cells significantly reduced their migration.116,117 In addition, in a murine sarcoma model, exosome-mediated delivery of siTGF-β1-inhibited TGF-β signaling, tumor growth, and lung metastases.118 More investigations are needed to evaluate the potential of exosomes as delivery systems for targeted therapy in sarcomas. The gene discussed is MMP13; the disease is sarcoma.