DDIT3 and osteosarcoma: Indeed, the overexpression of FUS-CHOP combined with loss of p53 in murine MSCs induced liposarcoma-like tumors.121 Furthermore, c-Myc overexpression was sufficient to transform murine bone marrow (BM)-MSCs into osteosarcoma in vivo and when combined with loss of the Ink4a/Arf locus, the process was substantially accelerated.122 The authors further showed that these osteosarcoma cells consisted of two subpopulations with one showing altered tri-lineage differentiation potential and resistance to conventional anti-cancer drugs.