Indeed, c-Myc is upregulated in a number of sarcomas including leiomyosarcoma, osteosarcoma, chondrosarcoma, synovial sarcoma, ARMS and EwS.32–39 Myc is a basic helix–loop–helix zipper transcription factor that regulates its target genes by binding to a conserved E-box DNA sequence CACGTG.40 It mainly exerts its effect on the cell cycle by transcriptionally activating cyclins and CDKs or by repressing p15INK4b, p21CIP1, and p27KIP1. This evidence concerns the gene MYC and synovial sarcoma.