VEGFA and osteosarcoma: For example, in osteosarcoma patients, those with VEGF-positive tumors had a significantly higher incidence of pulmonary metastases and worse overall survival compared to those with VEGF-negative tumors.79 Finally, overexpression of VEGF in STS cell lines led to accelerated growth and formation of highly vascular tumors, pulmonary metastases and chemoresistance in experimental models in vivo.80