After CDKN2A and PTEN-associated FDs, the genetic lesion occurring at FRA4F represents the most pervasive deletion across tumour types (Glover et al, 2017), affecting especially tumours of the gastroenteric tract, where it involves up to 18% of cases (Fig 1D and Table S2 and [Nancarrow et al, 2008; Bignell et al, 2010; Zack et al, 2013; Glover et al, 2017]). The gene discussed is PTEN; the disease is neoplasm.