ZC3H14 and Alzheimer disease: The same genetic approach uncovered sut-2 as a genetic suppressor of tauopathy [16], and subsequent translational studies revealed that the mammalian homolog of sut-2 (MSUT2) also resides in nuclear speckles and plays a critical role in tau aggregation and neurodegeneration in mice, human cells, and AD brain tissue [19, 25].