ALOX15 and Alzheimer disease: AD brains showed increased expression of 15-LOX-1 [104], and similarly, we found higher levels of this enzyme in the App KI mice at an age (18 months) when an increase in 15-HETE, 17-HDHA, and LXA4 levels, all of which are products of 15-LOX-1 enzyme activity, takes place [8, 29, 52].