Relative to miR-1291 mimic, co-transfection of pcDNA3.1-HCP5 and miR-1291 mimic partially rescued cell viability of AML cells, and the cell proliferation of si-PIK3R5 group was also promoted by the HCP5 overexpression (Fig. 5A). Here, HCP5 is linked to acute myeloid leukemia.