MiR-145, another pro-PNI miRNA, generated by colorectal cancer cells in the form of microvesicles, are transported to TAMs, where it weakens histone deacetylase 11 (HDAC11) expression, consequently educating and accelerating their differentiation towards M2-like phenotype and boosting tumor progression [161]. The gene discussed is HDAC11; the disease is colorectal cancer.