The inflammatory response triggered by the oxidative stress of mononuclear cells is another major cause of target organ damage observed in GVHD; thus, in this study, we further analyzed the regulation effects of hPMSCs on the Nrf2 and NF-κB pathways in mononuclear cells in the liver and spleen of the GVHD mouse model. The gene discussed is NFKB1; the disease is graft versus host disease.