There was also strong evidence for colocalization between an IEAA-associated locus on chromosome 15 (lead SNP rs12903325), and an eQTL for the lipid transporter gene ATP8B4, which contains variants that have been reported in relation to centenarian status in Italians and Alzheimer’s disease [67, 68]. This evidence concerns the gene ATP8B4 and early-onset autosomal dominant Alzheimer disease.