The higher rate of proliferation and greater survival advantage of HTLV-1 infected cells harboring Tax-mimicking mutations and negative selection of other clones in ATLL may explain the narrower and more uniform clonality of ATLL CD4+ T-cells compared to those of HTLV-1 associated myelopathy/Tropic spastic paraparesis (HAM/TSP) patients and asymptomatic carriers [18]. This evidence concerns the gene CD4 and adult T-cell leukemia/lymphoma.