The analysis highlighted the following pathways for each DEM: hsa-let-7a: Endometrial cancer, Colorectal cancer, Renin secretion, Cocaine addiction, TNF signaling pathway, Human T-cell leukemia virus 1 infection, Thyroid hormone signaling pathway, Human cytomegalovirus infection, Renal cell carcinoma, Cortisol synthesis and secretion. Here, REN is linked to renal cell carcinoma.