Several factors lead to the hypercoagulability state in patients with severe cases of COVID-19: circulatory stasis from immobility (common to intensive care patients), acute inflammatory reaction overdrive with increases in acute phase proteins (e.g., fibrinogen, c-reactive protein) and elevated clotting factors, increased Von Willebrand Factor (vWF) activity, neutrophilia, and increase in Neutrophil Extracellular traps (NETs) [14]. The gene discussed is VWF; the disease is thrombophilia.