In U-CLL, the following combinations were capable of predicting RFS within 15 months, 18 months, 3 years and 5 years: CRY1 + RELL1/CNTNAP2 + HOMER3 (AUC 84.66%), SLC7A5 + URAHP + FAM166A/CNTNAP2 + HOMER3 + MACC1 (AUC 81.64%), CKS2 + FAM166A/HOMER3 + ADAM29 (AUC79.55%), and UNC93B2 + SLC7A5/APOD + ADAM29 (AUC 82.91%). This evidence concerns the gene CRY1 and B-cell chronic lymphocytic leukemia.