To identify B cell specific functional interactions between CLL biomarkers (BTK, TP53, BCL2, ZAP70, NOTCH1, CXCR5, and ATM) and hub genes of their assigned modules, we used Genome-wide Integrated Analysis of gene Networks in Tissues (GIANTv2) [30]. Here, BTK is linked to B-cell chronic lymphocytic leukemia.