We found that blood levels of creatine, HbAlc, BUN, HDL, AST, ALT, CO2CP, glucose, potassium, ketones, hs-TnT, BNP, TG, TC, lactate, lactate and pH, and frequency of diabetic ketoacidosis, type of diabetes, duration of diabetes, vascular complications rates, and abdominal pain rates were significantly different among DKA-AP, DKA and control groups. The gene discussed is NPPB; the disease is diabetic ketoacidosis.