SPP1 and cancer: Given the fact that multiple earlier report in both OPN and NFAT studies suggested a connection with drug related redox stress in cancers, we extracted 80 genes from Gene Set Enrichment Analysis (GSEA) panels (Table S2) and found that 12 genes were identified as positively identified as DE with statistical significance between NFATc2 and NFATc2M samples (Fig. 4C).