Stable predictors that showed significant associations with the risk of HCC development in > 85% of 1000 different resampled datasets were age, sex, obesity, income level, the family history of chronic liver disease, ALT, gamma-glutamyl transpeptidase (GGT), total blood cholesterol level, and preexisting chronic liver disease, chronic hepatitis virus infection, HIV infection, DM, dyslipidemia, or schizophrenic/delusional disorders or mental disorders due to psychoactive substance use (Supplementary Table 4). The gene discussed is GGTLC1; the disease is obesity due to melanocortin 4 receptor deficiency.