By conducting multivariate analysis, we found that, in addition to neoplasm disease stage and diagnosis age, the expression levels of KLRG1, BTK, CCR2 and SCML4 were all independent prognostic factor for OS (hazard ratio, HR = 1.658 and P = 0.002 for KLRG1; HR = 1.889 and P < 0.001 for BTK; HR = 1.922 and P < 0.001 for CCR2; HR = 1.638 and P = 0.001 for SCML4) in LUAD patients (Table 5). This evidence concerns the gene BTK and neoplasm.