However, MR analysis found that a per 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using two synthesis SNPs (DHCR7-rs12785878 + CYP2R1-rs10741657) was associated with an increasing risk of T2D (OR [95%CI]: 1.10 [1.02–1.45]) and abnormal DBP (1.14 [1.03–1.43]). The gene discussed is CYP2R1; the disease is type 2 diabetes mellitus.