Moreover, Madala, Satish K et al. have shown that using MEK inhibitor ARRY-142,886 (ARRY) to treat lung fibrosis model mice can prevent lung cell proliferation and increase in total lung collagen, and protect mice from changes in lung function, indicating that MEK/ERK activation plays an important role in human PF [49]. The gene discussed is MAP2K7; the disease is pulmonary fibrosis.