From the pathways identified and putative links to PAH pathogenesis, seven gene targets (FER, GLMN, PARP8, MTUS1, HGF, PELI1 and UBR3) were selected for qPCR validation using 4 control human pulmonary artery smooth muscle cells (PASMC) and 4 with IPAH [37]. Here, PARP8 is linked to pulmonary arterial hypertension.