These data show that transcripts from seven proteins prioritized in our multi-omics approach, ALDH7A1, CAD, CANT1, GOT1, MTHFD1, PYGB and SARS, are associated with prognosis in HNSCC or other tumor types and may be further evaluated as clinical markers in the disease. The gene discussed is PYGB; the disease is head and neck squamous cell carcinoma.