Besides that, low transcript levels retrieved from TCGA primary tumors for three of the 11 ‘hub proteins’ (ALDH7A1, GOT1, MTHFD1) were associated with poor overall survival in renal and cervical cancer (p-value ≤ 0.05; Human Protein Atlas platform) (supplemental Fig. S4C; supplemental Table S20). The gene discussed is MTHFD1; the disease is cervical cancer.