The role of BAP1 in preventing intergenic spreading of H3K27me3 and chromatin compaction is reminiscent of EZH2 gain-of-function cancers such as non- Hodgkin’s lymphoma (Morin et al., 2011) in which genome-wide H3K27me3 accumulation correlates with local increases in compaction and transcriptional inactivation of affected TADs (Donaldson-Collier et al., 2019). The gene discussed is EZH2; the disease is cancer.