Systematic review. The authors conducted an electronic search across PubMed, Medline, PsycINFO, ScienceDirect, Google Scholar, Embase library databases for English, peer-reviewed, articles and reviews published after 1964 using the following MeSH terms: Alzheimer's Disease (AD) AND Models, Reactive Oxygen Species (ROS) AND/OR Oxidative Stress (OS) AND Astaxanthin (AS) AND models, Superoxide dismutase (SOD) AND models. The gene discussed is SOD1; the disease is Alzheimer disease.