Moreover, for very early HCC (mUICC stage I), the combinations of EV‐DLEU2 and EV‐MALAT1, and EV‐HOTTIP and EV‐MALAT1 exhibited the best AUCs (0.921, 95% CI 0.854–0.987, and 0.921, 95% CI 0.856–0.986, respectively) in a model of HCC vs. nontumor, whereas the combination of EV‐MALAT1 and EV‐SNHG1 had the best AUC (0.899, 95% CI 0.816–0.982) in a model of HCC vs. CH/LC. Here, MALAT1 is linked to hepatocellular carcinoma.