This study compared the lncRNA expression between HCC and non‐HCC tissues using two RNA‐sequencing datasets, resulting in the identification of six lncRNAs (DLEU2, HOTTIP, MALAT1, NEAT1, SNHG1, and TUG1) as candidate biomarkers for HCC diagnosis. This evidence concerns the gene SNHG1 and hepatocellular carcinoma.