A recent study evaluating eight serum lncRNAs including serum MALAT1 reported an acceptable AUC (0.733, 95% CI = 0.676–0.790) with 59.7% sensitivity and 75.7% specificity in a model of HCC vs. LC, CHB, and healthy controls; however, this was lower than the AUC for AFP (0.811) [20]. Here, AFP is linked to laryngotracheoesophageal cleft.