Still further, the AFP and EV‐DLEU2 combination exhibited the highest positivity for all‐stage (92%) and mUICC stage I HCC (96%), whereas EV‐DLEU2 and AFP or EV‐HOTTIP or EV‐SNHG1 showed the highest positivity (95% for each combination) for mUICC stage I or II HCC. Here, AFP is linked to hepatocellular carcinoma.