TUBA1A and obstructive sleep apnea syndrome: Thus, on one hand, CIH and OSA may downregulate TUBA1A, resulting in the reduction of microtubule formation and obstruction of intracellular transport of neurons, leading to synaptic dysfunction and cognitive dysfunction; on the other hand, the reduction of TUBA1A reduces the regulation of reversible lysosase-acetylation and affects the construction of axonal microtubules, leading to insufficient sperm motility and male hypogonadism.