Note that only those predictions, associated to HLA alleles with established connection to RA across the literature (S9 Table), were considered as true epitope candidates (predictions associated to HLA alleles DRB5*01:01, DQA1*01:01/DQB1*05:01, and DQA1*04:01/DQB1*04:02 were excluded from further analysis). The gene discussed is HLA-DRB5; the disease is rheumatoid arthritis.